AN UNBIASED VIEW OF TETRAHYDROBIOPTERINPKU

BH4 metabolism can as a substitute be depicted to be a cytoprotective pathway that is finely controlled because of the concerted action of de novo, salvage, and recycling pathways to regulate intracellular concentrations of BH4 and BH4-associated metabolites. If this finely tuned equilibrium in BH4 focus is perturbed, many biological systems are co